Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis
Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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PRG4 is an extracellular matrix protein that maintains homeostasis through its boundary lubricating and anti-inflammatory properties. Altered expression and function of PRG4 have been associated with joint inflammatory diseases, including osteoarthritis. Here we show that mast cell tryptase β cleaves PRG4 in a dose- and time-dependent manner, which...
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Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis
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TN_cdi_doaj_primary_oai_doaj_org_article_acd1e0dd071f4882af74316106133957
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_acd1e0dd071f4882af74316106133957
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-37598-3
