The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitoph...
The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Although mitophagy is known to restrict NLRP3 inflammasome activation, the underlying regulatory mechanism remains poorly characterized. Here we describe a type of early endosome-dependent mitophagy that limits NLRP3 inflammasome activation. Deletion of the endosomal adaptor protein APPL1 impairs mitophagy, leading to accumulation of damaged mitoch...
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The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages
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TN_cdi_doaj_primary_oai_doaj_org_article_acd1f474dbe44e05886bd6aede2b54b2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_acd1f474dbe44e05886bd6aede2b54b2
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26987-1
