Impaired cortico-striatal excitatory transmission triggers epilepsy
Impaired cortico-striatal excitatory transmission triggers epilepsy
About this item
Full title
Author / Creator
Miyamoto, Hiroyuki , Tatsukawa, Tetsuya , Shimohata, Atsushi , Yamagata, Tetsushi , Suzuki, Toshimitsu , Amano, Kenji , Mazaki, Emi , Raveau, Matthieu , Ogiwara, Ikuo , Oba-Asaka, Atsuko , Hensch, Takao K. , Itohara, Shigeyoshi , Sakimura, Kenji , Kobayashi, Kenta , Kobayashi, Kazuto and Yamakawa, Kazuhiro
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
STXBP1
and
SCN2A
gene mutations are observed in patients with epilepsies, although the circuit basis remains elusive. Here, we show that mice with haplodeficiency for these genes exhibit absence seizures with spike-and-wave discharges (SWDs) initiated by reduced cortical excitatory transmission into the striatum. Mice deficient for
Stxb...
Alternative Titles
Full title
Impaired cortico-striatal excitatory transmission triggers epilepsy
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ace6b971d0ec4f8d94660e10cc120cb0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ace6b971d0ec4f8d94660e10cc120cb0
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09954-9
