The disruption of the CCDC6 – PP4 axis induces a BRCAness like phenotype and sensitivity to PARP inh...
The disruption of the CCDC6 – PP4 axis induces a BRCAness like phenotype and sensitivity to PARP inhibitors in high-grade serous ovarian carcinoma
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London: BioMed Central Ltd
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English
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London: BioMed Central Ltd
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Background Treatment with PARP inhibitors (PARPi) is primarily effective against high-grade serous ovarian cancers (HGSOC) with BRCA1/2 mutations or other deficiencies in homologous recombination (HR) repair mechanisms. However, resistance to PARPi frequently develops, mostly as a result of BRCA1/2 reversion mutations. The tumour suppressor CCDC6 i...
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The disruption of the CCDC6 – PP4 axis induces a BRCAness like phenotype and sensitivity to PARP inhibitors in high-grade serous ovarian carcinoma
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TN_cdi_doaj_primary_oai_doaj_org_article_adbdda7216ee4ee5a177948cec916279
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_adbdda7216ee4ee5a177948cec916279
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1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-022-02459-2
