Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation
Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models suggest that fluid resuscitation degrades the endothelial glycocalyx, a heparan sulfate-enriched structure necessary for vascular homeostasis. We hypothesized that endothelial glycocalyx degrad...
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Full title
Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation
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TN_cdi_doaj_primary_oai_doaj_org_article_ae7b20a88cc94d08add62de6c3bc9b4b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ae7b20a88cc94d08add62de6c3bc9b4b
Other Identifiers
ISSN
1364-8535
E-ISSN
1466-609X,1364-8535
DOI
10.1186/s13054-019-2534-2
