Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features
Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features
About this item
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Author / Creator
Magaret, Craig A. , Li, Li , deCamp, Allan C. , Rolland, Morgane , Juraska, Michal , Williamson, Brian D. , Ludwig, James , Molitor, Cindy , Benkeser, David , Luedtke, Alex , Simpkins, Brian , Heng, Fei , Sun, Yanqing , Carpp, Lindsay N. , Bai, Hongjun , Dearlove, Bethany L. , Giorgi, Elena E. , Jongeneelen, Mandy , Brandenburg, Boerries , McCallum, Matthew , Bowen, John E. , Veesler, David , Sadoff, Jerald , Gray, Glenda E. , Roels, Sanne , Vandebosch, An , Stieh, Daniel J. , Le Gars, Mathieu , Vingerhoets, Johan , Grinsztejn, Beatriz , Goepfert, Paul A. , de Sousa, Leonardo Paiva , Silva, Mayara Secco Torres , Casapia, Martin , Losso, Marcelo H. , Little, Susan J. , Gaur, Aditya , Bekker, Linda-Gail , Garrett, Nigel , Truyers, Carla , Van Dromme, Ilse , Swann, Edith , Marovich, Mary A. , Follmann, Dean , Neuzil, Kathleen M. , Corey, Lawrence , Greninger, Alexander L. , Roychoudhury, Pavitra , Hyrien, Ollivier and Gilbert, Peter B.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
In the ENSEMBLE randomized, placebo-controlled phase 3 trial (NCT04505722), estimated single-dose Ad26.COV2.S vaccine efficacy (VE) was 56% against moderate to severe–critical COVID-19. SARS-CoV-2 Spike sequences were determined from 484 vaccine and 1,067 placebo recipients who acquired COVID-19. In this set of prespecified analyses, we show that i...
Alternative Titles
Full title
Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features
Authors, Artists and Contributors
Author / Creator
Li, Li
deCamp, Allan C.
Rolland, Morgane
Juraska, Michal
Williamson, Brian D.
Ludwig, James
Molitor, Cindy
Benkeser, David
Luedtke, Alex
Simpkins, Brian
Heng, Fei
Sun, Yanqing
Carpp, Lindsay N.
Bai, Hongjun
Dearlove, Bethany L.
Giorgi, Elena E.
Jongeneelen, Mandy
Brandenburg, Boerries
McCallum, Matthew
Bowen, John E.
Veesler, David
Sadoff, Jerald
Gray, Glenda E.
Roels, Sanne
Vandebosch, An
Stieh, Daniel J.
Le Gars, Mathieu
Vingerhoets, Johan
Grinsztejn, Beatriz
Goepfert, Paul A.
de Sousa, Leonardo Paiva
Silva, Mayara Secco Torres
Casapia, Martin
Losso, Marcelo H.
Little, Susan J.
Gaur, Aditya
Bekker, Linda-Gail
Garrett, Nigel
Truyers, Carla
Van Dromme, Ilse
Swann, Edith
Marovich, Mary A.
Follmann, Dean
Neuzil, Kathleen M.
Corey, Lawrence
Greninger, Alexander L.
Roychoudhury, Pavitra
Hyrien, Ollivier
Gilbert, Peter B.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ae82624b40e944a5925f8f3c70ded9b7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ae82624b40e944a5925f8f3c70ded9b7
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-46536-w
