Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Activation of endothelial YAP/TAZ signaling is crucial for physiological and pathological angiogenesis. The mechanisms of endothelial YAP/TAZ regulation are, however, incompletely understood. Here we report that the protocadherin FAT1 acts as a critical upstream regulator of endothelial YAP/TAZ which limits the activity of these transcriptional cof...
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Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
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TN_cdi_doaj_primary_oai_doaj_org_article_ae8cf225971e49d0b6bc0f0653d4b7c5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ae8cf225971e49d0b6bc0f0653d4b7c5
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-37671-x
