Ratatosk: hybrid error correction of long reads enables accurate variant calling and assembly
Ratatosk: hybrid error correction of long reads enables accurate variant calling and assembly
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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A major challenge to long read sequencing data is their high error rate of up to 15%. We present Ratatosk, a method to correct long reads with short read data. We demonstrate on 5 human genome trios that Ratatosk reduces the error rate of long reads 6-fold on average with a median error rate as low as 0.22 %. SNP calls in Ratatosk corrected reads a...
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Ratatosk: hybrid error correction of long reads enables accurate variant calling and assembly
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TN_cdi_doaj_primary_oai_doaj_org_article_ae95bd781a544d83a00154b7906d8e9c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ae95bd781a544d83a00154b7906d8e9c
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ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-020-02244-4
