Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK
Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK
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Author / Creator
Peng, Chang , Jiang, Haowen , Jing, Liya , Yang, Wenhua , Guan, Xiaotong , Wang, Hanlin , Yu, Sike , Cao, Yutang , Wang, Min , Ma, Huan , Lv, Zan , Gu, Hongyu , Xia, Chunmei , Guo, Xiaozhen , Sun, Bin , Wang, Aili , Xie, Cen , Wu, Wenbiao , Lu, Luyiyi , Song, Jiayi , Lei, Saifei , Wu, Rui , Zang, Yi , Tang, Erjiang and Li, Jia
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Obesity is regarded as a chronic inflammatory disease involving adipose tissue macrophages (ATM), but whether immunometabolic reprogramming of ATM affects obesity remains unclarified. Here we show that in ATM glutaminolysis is the fundamental metabolic flux providing energy and substrate, bridging with AMP-activated protein kinase (AMPK) activity,...
Alternative Titles
Full title
Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK
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TN_cdi_doaj_primary_oai_doaj_org_article_ae98927944814b38b83acabbcd7d2c22
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ae98927944814b38b83acabbcd7d2c22
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-57044-w
