Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
About this item
Full title
Author / Creator
Qiao, Wenhui , Chen, Yixing , Zhong, Jun , Madden, Benjamin J. , Charlesworth, Cristine M. , Martens, Yuka A. , Liu, Chia-Chen , Knight, Joshua , Ikezu, Tadafumi C. , Kurti, Aishe , Zhu, Yiyang , Meneses, Axel , Rosenberg, Cassandra L. , Kuchenbecker, Lindsey A. , Vanmaele, Lucy K. , Li, Fuyao , Chen, Kai , Shue, Francis , Dacquel, Maxwell V. , Fryer, John , Pandey, Akhilesh , Zhao, Na and Bu, Guojun
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
The rare p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) was found to increase Alzheimer's disease (AD) risk. This mutation is located at the cleavage site of TREM2 extracellular domain. Ectopic expression of TREM2-H157Y in HEK293 cells resulted in increased TREM2 shedding. However, the physiological outcomes of the TREM...
Alternative Titles
Full title
Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
Authors, Artists and Contributors
Author / Creator
Chen, Yixing
Zhong, Jun
Madden, Benjamin J.
Charlesworth, Cristine M.
Martens, Yuka A.
Liu, Chia-Chen
Knight, Joshua
Ikezu, Tadafumi C.
Kurti, Aishe
Zhu, Yiyang
Meneses, Axel
Rosenberg, Cassandra L.
Kuchenbecker, Lindsey A.
Vanmaele, Lucy K.
Li, Fuyao
Chen, Kai
Shue, Francis
Dacquel, Maxwell V.
Fryer, John
Pandey, Akhilesh
Zhao, Na
Bu, Guojun
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_aeb26e05f9954b82bf1169b444687ab2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_aeb26e05f9954b82bf1169b444687ab2
Other Identifiers
ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-023-00599-3
