Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Re...
Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway
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Publisher
Switzerland: MDPI
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Language
English
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Publisher
Switzerland: MDPI
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Contents
Besides their antiviral and immunomodulatory functions, type I (α/β) and II (γ) interferons (IFNs) exhibit either beneficial or detrimental effects on tumor progression. Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of abnormal CD5
B lymphocytes that escape death. Drug resistance and disease relapse still occur in CLL....
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Full title
Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway
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TN_cdi_doaj_primary_oai_doaj_org_article_aef6fc81636a413d9c158bb84cd92e9c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_aef6fc81636a413d9c158bb84cd92e9c
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ISSN
2227-9059
E-ISSN
2227-9059
DOI
10.3390/biomedicines9020188
