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A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-bi...

A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-bi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_aefe8ebe00214c9e806ed4b35d6ebf37

A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding

About this item

Full title

A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2024-12, Vol.15 (1), p.10656-16, Article 10656

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The SARS-CoV-2 nucleocapsid protein is indispensable for viral RNA genome processing. Although the N-terminal domain (NTD) is suggested to mediate specific RNA-interactions, high-resolution structures with viral RNA are still lacking. Available hybrid structures of the NTD with ssRNA and dsRNA provide valuable insights; however, the precise mechani...

Alternative Titles

Full title

A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_aefe8ebe00214c9e806ed4b35d6ebf37

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_aefe8ebe00214c9e806ed4b35d6ebf37

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-024-55024-0

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