Biphasic response as a mechanism against mutant takeover in tissue homeostasis circuits
Biphasic response as a mechanism against mutant takeover in tissue homeostasis circuits
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Author / Creator
Karin, Omer and Alon, Uri
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Tissues use feedback circuits in which cells send signals to each other to control their growth and survival. We show that such feedback circuits are inherently unstable to mutants that misread the signal level: Mutants have a growth advantage to take over the tissue, and cannot be eliminated by known cell‐intrinsic mechanisms. To resolve this, we...
Alternative Titles
Full title
Biphasic response as a mechanism against mutant takeover in tissue homeostasis circuits
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TN_cdi_doaj_primary_oai_doaj_org_article_af0eb7e24aec44bfa14dd3fa157ce827
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_af0eb7e24aec44bfa14dd3fa157ce827
Other Identifiers
ISSN
1744-4292
E-ISSN
1744-4292
DOI
10.15252/msb.20177599
