Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leu...
Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia
About this item
Full title
Author / Creator
Wang, Feng , Morita, Kiyomi , DiNardo, Courtney D. , Furudate, Ken , Tanaka, Tomoyuki , Yan, Yuanqing , Patel, Keyur P. , MacBeth, Kyle J. , Wu, Bin , Liu, Guowen , Frattini, Mark , Matthews, Jairo A. , Little, Latasha D. , Gumbs, Curtis , Song, Xingzhi , Zhang, Jianhua , Thompson, Erika J. , Kadia, Tapan M. , Garcia-Manero, Guillermo , Jabbour, Elias , Ravandi, Farhad , Bhalla, Kapil N. , Konopleva, Marina , Kantarjian, Hagop M. , Andrew Futreal, P. and Takahashi, Koichi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Allosteric inhibitors of mutant IDH1 or IDH2 induce terminal differentiation of the mutant leukemic blasts and provide durable clinical responses in approximately 40% of acute myeloid leukemia (AML) patients with the mutations. However, primary resistance and acquired resistance to the drugs are major clinical issues. To understand the molecular un...
Alternative Titles
Full title
Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia
Authors, Artists and Contributors
Author / Creator
Morita, Kiyomi
DiNardo, Courtney D.
Furudate, Ken
Tanaka, Tomoyuki
Yan, Yuanqing
Patel, Keyur P.
MacBeth, Kyle J.
Wu, Bin
Liu, Guowen
Frattini, Mark
Matthews, Jairo A.
Little, Latasha D.
Gumbs, Curtis
Song, Xingzhi
Zhang, Jianhua
Thompson, Erika J.
Kadia, Tapan M.
Garcia-Manero, Guillermo
Jabbour, Elias
Ravandi, Farhad
Bhalla, Kapil N.
Konopleva, Marina
Kantarjian, Hagop M.
Andrew Futreal, P.
Takahashi, Koichi
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_af530f137f2d430f8c1dd47dd38789db
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_af530f137f2d430f8c1dd47dd38789db
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22874-x
