BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer
BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer
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Author / Creator
Li, Kun , Liu, Yanan , Ding, Yi , Zhang, Zhengwei , Feng, Juanjuan , Hu, Jiaxin , Chen, Jiwei , Lian, Zhengke , Chen, Yiliang , Hu, Kewen , Chen, Zhi , Cai, Zhenyu , Liu, Mingyao and Pang, Xiufeng
Publisher
Ann Arbor: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
Ann Arbor: American Society for Clinical Investigation
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Contents
Mutational activation of KRAS is a common oncogenic event in lung cancer, yet effective therapies are still lacking. Here, we identify B cell lymphoma 6 (BCL6) as a lynchpin in KRAS-driven lung cancer. BCL6 expression was increased upon KRAS activation in lung tumor tissue in mice and was positively correlated with the expression of KRAS-GTP, the a...
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Full title
BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_af61bce617fb4998b7196414b047c45d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_af61bce617fb4998b7196414b047c45d
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI161308
