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An essential role for TASL in mouse autoimmune pathogenesis and Toll-like receptor signaling

An essential role for TASL in mouse autoimmune pathogenesis and Toll-like receptor signaling

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_af6ca7ac882943998a6fc3ccaf23006c

An essential role for TASL in mouse autoimmune pathogenesis and Toll-like receptor signaling

About this item

Full title

An essential role for TASL in mouse autoimmune pathogenesis and Toll-like receptor signaling

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2025-01, Vol.16 (1), p.968-12, Article 968

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

TASL is an immune adaptor that binds to the solute carrier SLC15A4 and facilitates activation of the transcription factor IRF5 during Toll-like receptor (TLR) signaling. Similar to
IRF5
and
SLC15A4
, single nucleotide polymorphisms (SNPs) within
TASL
have been implicated in increased susceptibility to systemic lupus erythematosus...

Alternative Titles

Full title

An essential role for TASL in mouse autoimmune pathogenesis and Toll-like receptor signaling

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_af6ca7ac882943998a6fc3ccaf23006c

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_af6ca7ac882943998a6fc3ccaf23006c

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-024-55690-0

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