Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar...
Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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In 2006, mutations in the granulin gene were identified in patients with familial Frontotemporal Lobar Degeneration. Granulin transcript haploinsufficiency has been proposed as a disease mechanism that leads to the loss of functional progranulin protein. Granulin mutations were initially found in tau-negative patients, though recent findings indica...
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Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation
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TN_cdi_doaj_primary_oai_doaj_org_article_afd44deb62a8416980a2d0acb1a3fb39
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_afd44deb62a8416980a2d0acb1a3fb39
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-01587-6
