Combined inhibition of BET proteins and class I HDACs synergistically induces apoptosis in urothelia...
Combined inhibition of BET proteins and class I HDACs synergistically induces apoptosis in urothelial carcinoma cell lines
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Germany: BioMed Central Ltd
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Language
English
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Germany: BioMed Central Ltd
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New efficient therapies for urothelial carcinoma (UC) are urgently required. Small-molecule drugs targeting chromatin regulators are reasonable candidates because these regulators are frequently mutated or deregulated in UC. Indeed, in previous work, Romidepsin, which targets class I histone deacetylases (HDAC), efficiently killed UC cells, but did...
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Full title
Combined inhibition of BET proteins and class I HDACs synergistically induces apoptosis in urothelial carcinoma cell lines
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TN_cdi_doaj_primary_oai_doaj_org_article_afd75562c767409abec905e2e04a6cfb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_afd75562c767409abec905e2e04a6cfb
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ISSN
1868-7075
E-ISSN
1868-7083
DOI
10.1186/s13148-017-0434-3
