Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling
Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Inflammation influences cancer development, progression, and the efficacy of cancer treatments, yet the mechanisms by which immune signaling drives alterations in the cancer cell transcriptome remain unclear. Using ChIP-seq, RNA-seq, and GRO-seq, here we demonstrate a global overlap in the binding of tumor-promoting p53 mutants and the master proin...
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Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling
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TN_cdi_doaj_primary_oai_doaj_org_article_afeca2176ca641f4a733a0cf6b0463bc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_afeca2176ca641f4a733a0cf6b0463bc
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01117-y
