Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiov...
Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Tight control of cell fate choices is crucial for normal development. Here we show that lamin A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which safeguards naïve pluripotency and ensures proper cell fate choices during cardiogenesis. We report changes in chromatin compaction and localization of cardiac genes in
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Full title
Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function
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TN_cdi_doaj_primary_oai_doaj_org_article_affb57fd818c4607ac29bd5aca976eb1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_affb57fd818c4607ac29bd5aca976eb1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34366-7
