Hepatocyte-specific TMEM16A deficiency alleviates hepatic ischemia/reperfusion injury via suppressin...
Hepatocyte-specific TMEM16A deficiency alleviates hepatic ischemia/reperfusion injury via suppressing GPX4-mediated ferroptosis
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Author / Creator
Guo, Jiawei , Song, Zihao , Yu, Jie , Li, Chengyi , Jin, Chenchen , Duan, Wei , Liu, Xiu , Liu, Yingying , Huang, Shuai , Tuo, Yonghua , Pei, Fei , Jian, Zhengyang , Zhou, Pengyu , Zheng, Shaoyi , Zou, Zhaowei , Zhang, Feng , Gong, Quan and Liang, Sijia
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major complication of liver transplantation. Transmembrane member 16A (TMEM16A), a component of hepatocyte Ca
2+
-activated chloride channel, has been implicated in a variety of liver diseases. However, its role in hepatic I/R injury remains unknown. Here, mice with h...
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Full title
Hepatocyte-specific TMEM16A deficiency alleviates hepatic ischemia/reperfusion injury via suppressing GPX4-mediated ferroptosis
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TN_cdi_doaj_primary_oai_doaj_org_article_b0a18edcac304942aad84069dea6bfd2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b0a18edcac304942aad84069dea6bfd2
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-022-05518-w
