Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis
Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The pH in atherosclerotic lesions varies between individuals. IgE activates macrophage Na
+
-H
+
exchanger (Nhe1) and induces extracellular acidification and cell apoptosis. Here, we show that the pH-sensitive pHrodo probe localizes the acidic regions in atherosclerotic lesions to macrophages, IgE, and cell apoptosis. In
Apoe
–/–<...
Alternative Titles
Full title
Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b0bd30f23bbe46f4ac1f69c4a193d1c1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b0bd30f23bbe46f4ac1f69c4a193d1c1
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11983-3
