Evidence supporting a catalytic pentad mechanism for the proteasome and other N-terminal nucleophile...
Evidence supporting a catalytic pentad mechanism for the proteasome and other N-terminal nucleophile enzymes
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Proteases are defined by their nucleophile but require additional residues to regulate their active sites, most often arranged as catalytic triads that control the generation and resolution of acyl-enzyme intermediates. Threonine N-terminal nucleophiles represent a diverse family of proteases and transferases that possess two active site nucleophil...
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Full title
Evidence supporting a catalytic pentad mechanism for the proteasome and other N-terminal nucleophile enzymes
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TN_cdi_doaj_primary_oai_doaj_org_article_b11a9305566844e8ac7e9252b972e34e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b11a9305566844e8ac7e9252b972e34e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-58077-x
