Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiol...
Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5
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Switzerland: Frontiers Research Foundation
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English
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Switzerland: Frontiers Research Foundation
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Mitochondrial integrity is fundamental to cellular function, upheld by a network of proteases that regulate proteostasis and mitochondrial dynamics. Among these proteases, AFG3L2 is critical due to its roles in maintaining mitochondrial homeostasis, regulating mitochondrial protein quality, and facilitating mitochondrial biogenesis. Mutations in AF...
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Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5
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TN_cdi_doaj_primary_oai_doaj_org_article_b1ca7cf5a3bf491fa878e1fbd2e968be
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b1ca7cf5a3bf491fa878e1fbd2e968be
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1662-5099
E-ISSN
1662-5099
DOI
10.3389/fnmol.2025.1548255
