RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia
RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia
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Author / Creator
Lipka, Daniel B. , Witte, Tania , Toth, Reka , Yang, Jing , Wiesenfarth, Manuel , Nöllke, Peter , Fischer, Alexandra , Brocks, David , Gu, Zuguang , Park, Jeongbin , Strahm, Brigitte , Wlodarski, Marcin , Yoshimi, Ayami , Claus, Rainer , Lübbert, Michael , Busch, Hauke , Boerries, Melanie , Hartmann, Mark , Schönung, Maximilian , Kilik, Umut , Langstein, Jens , Wierzbinska, Justyna A. , Pabst, Caroline , Garg, Swati , Catalá, Albert , De Moerloose, Barbara , Dworzak, Michael , Hasle, Henrik , Locatelli, Franco , Masetti, Riccardo , Schmugge, Markus , Smith, Owen , Stary, Jan , Ussowicz, Marek , van den Heuvel-Eibrink, Marry M. , Assenov, Yassen , Schlesner, Matthias , Niemeyer, Charlotte , Flotho, Christian and Plass, Christoph
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative disorder of early childhood characterized by mutations activating RAS signaling. Established clinical and genetic markers fail to fully recapitulate the clinical and biological heterogeneity of this disease. Here we report DNA methylome analysis and mutation profiling of 16...
Alternative Titles
Full title
RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia
Authors, Artists and Contributors
Author / Creator
Witte, Tania
Toth, Reka
Yang, Jing
Wiesenfarth, Manuel
Nöllke, Peter
Fischer, Alexandra
Brocks, David
Gu, Zuguang
Park, Jeongbin
Strahm, Brigitte
Wlodarski, Marcin
Yoshimi, Ayami
Claus, Rainer
Lübbert, Michael
Busch, Hauke
Boerries, Melanie
Hartmann, Mark
Schönung, Maximilian
Kilik, Umut
Langstein, Jens
Wierzbinska, Justyna A.
Pabst, Caroline
Garg, Swati
Catalá, Albert
De Moerloose, Barbara
Dworzak, Michael
Hasle, Henrik
Locatelli, Franco
Masetti, Riccardo
Schmugge, Markus
Smith, Owen
Stary, Jan
Ussowicz, Marek
van den Heuvel-Eibrink, Marry M.
Assenov, Yassen
Schlesner, Matthias
Niemeyer, Charlotte
Flotho, Christian
Plass, Christoph
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b1e79a966ad24c1db61ab521bffa8d40
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b1e79a966ad24c1db61ab521bffa8d40
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02177-w
