Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability t...
Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation
About this item
Full title
Author / Creator
Zois, Christos E. , Hendriks, Anne M. , Haider, Syed , Pires, Elisabete , Bridges, Esther , Kalamida, Dimitra , Voukantsis, Dimitrios , Lagerholm, B. Christoffer , Fehrmann, Rudolf S. N. , den Dunnen, Wilfred F. A. , Tarasov, Andrei I. , Baba, Otto , Morris, John , Buffa, Francesca M. , McCullagh, James S. O. , Jalving, Mathilde and Harris, Adrian L.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Channelling of glucose via glycogen, known as the glycogen shunt, may play an important role in the metabolism of brain tumours, especially in hypoxic conditions. We aimed to dissect the role of glycogen degradation in glioblastoma (GBM) response to ionising radiation (IR). Knockdown of the glycogen phosphorylase liver isoform (PYGL), but not the b...
Alternative Titles
Full title
Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation
Authors, Artists and Contributors
Author / Creator
Hendriks, Anne M.
Haider, Syed
Pires, Elisabete
Bridges, Esther
Kalamida, Dimitra
Voukantsis, Dimitrios
Lagerholm, B. Christoffer
Fehrmann, Rudolf S. N.
den Dunnen, Wilfred F. A.
Tarasov, Andrei I.
Baba, Otto
Morris, John
Buffa, Francesca M.
McCullagh, James S. O.
Jalving, Mathilde
Harris, Adrian L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b1ef617fb3104ffda4ec574e955e7b3f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b1ef617fb3104ffda4ec574e955e7b3f
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-022-05005-2
