Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation
Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation
About this item
Full title
Author / Creator
Publisher
Switzerland: MDPI
Journal title
Language
English
Formats
Publication information
Publisher
Switzerland: MDPI
Subjects
More information
Scope and Contents
Contents
The discovery of multi-targeting ligands of bacterial enzymes is an important strategy to combat rapidly spreading antimicrobial resistance. Bacterial DNA gyrase and topoisomerase IV are validated targets for the development of antibiotics. They can be inhibited at their catalytic sites or at their ATP binding sites. Here we present the design of n...
Alternative Titles
Full title
Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b21ef8c08f5f42f5bcc65fa01c759cd9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b21ef8c08f5f42f5bcc65fa01c759cd9
Other Identifiers
ISSN
1999-4923
E-ISSN
1999-4923
DOI
10.3390/pharmaceutics13010006
