Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis
Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis
About this item
Full title
Author / Creator
Sun, Tong , Xu, Yujia , Xu, Zhuan , Cao, Biyin , Zhang, Zubin , Wang, Qi , Kong, Yan and Mao, Xinliang
Publisher
England: BioMed Central
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central
Subjects
More information
Scope and Contents
Contents
The oncogenic transcript factor c-Maf is stabilized by the deubiquitinase Otub1 and promotes myeloma cell proliferation and confers to chemoresistance. Inhibition of the Otub1/c-Maf axis is a promising therapeutic target, but there are no inhibitors reported on this specific axis.
A luciferase assay was applied to screen potential inhibitors of...
Alternative Titles
Full title
Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b25e24fa324e4d7bb073d4c12bf12118
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b25e24fa324e4d7bb073d4c12bf12118
Other Identifiers
ISSN
1478-811X
E-ISSN
1478-811X
DOI
10.1186/s12964-020-00676-w
