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Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 depe...

Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 depe...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b269b498eb06438890385181c12ba8bb

Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy

About this item

Full title

Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2023-08, Vol.14 (1), p.4622-4622, Article 4622

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Caspase recruitment-domain containing protein 9 (CARD9) is a key signaling pathway in macrophages but its role in atherosclerosis is still poorly understood. Global deletion of
Card9
in
Apoe
-/-
mice as well as hematopoietic deletion in
Ldlr
-/-
mice increases atherosclerosis. The acceleration of atherosclerosis is also obse...

Alternative Titles

Full title

Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_b269b498eb06438890385181c12ba8bb

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b269b498eb06438890385181c12ba8bb

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-023-40216-x

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