Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA
Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The expanded hexanucleotide GGGGCC repeat mutation in the
C9orf72
gene is the main genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Under one disease mechanism, sense and antisense transcripts of the repeat are predicted to bind various RNA-binding proteins, compromise their function and cause cytotoxicity. Here we...
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Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA
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TN_cdi_doaj_primary_oai_doaj_org_article_b29cd3b5c510491ea05a97aba7af8fed
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b29cd3b5c510491ea05a97aba7af8fed
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41511-3
