Selective tubulin-binding drugs induce pericyte phenotype switching and anti-cancer immunity
Selective tubulin-binding drugs induce pericyte phenotype switching and anti-cancer immunity
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The intratumoral immune milieu is crucial for the success of anti-cancer immunotherapy. We show here that stromal modulation by the tubulin-binding anti-cancer drugs combretastatin A4 (CA-4) and eribulin improved tumor perfusion and anti-tumor immunity. This was achieved by reverting highly proliferative, angiogenic pericytes into a quiescent, cont...
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Selective tubulin-binding drugs induce pericyte phenotype switching and anti-cancer immunity
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TN_cdi_doaj_primary_oai_doaj_org_article_b302e24d1b8746a3a58d90fea1170599
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b302e24d1b8746a3a58d90fea1170599
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ISSN
1757-4684,1757-4676
E-ISSN
1757-4684
DOI
10.1038/s44321-025-00222-6
