USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
About this item
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Author / Creator
Shao, Na , Xi, Lei , Lv, Yangfan , Idris, Muhammad , Zhang, Lin , Cao, Ya , Xiang, Jingyi , Xu, Xi , Ong, Belinda X. , Zhang, Qiongyi , Peng, Xu , Yue, Xiaoyan , Xu, Feng and Liu, Chungang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The N
6
-methyladenosine binding protein YTHDF1, often upregulated in cancer, promotes tumor growth and hinders immune checkpoint blockade treatment. A comprehensive understanding of the molecular mechanisms governing YTHDF1 protein stability is pivotal for enhancing clinical response rates and the effectiveness of immune checkpoint blockade...
Alternative Titles
Full title
USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b33de7d8fcaa481c9c10ad4eb7c98080
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b33de7d8fcaa481c9c10ad4eb7c98080
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-56564-9
