Rational design of environmentally responsive antibodies with pH-sensing synthetic amino acids
Rational design of environmentally responsive antibodies with pH-sensing synthetic amino acids
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Antibodies are widely used as therapeutic agents to tackle various diseases. In the present study, to enhance their clinical values, we rationally designed pH-responsivity by exploiting the idiosyncratic protonation/deprotonation profiles of non-natural amino acids. 3-Nitro-
l
-tyrosine, 3-cyano-
l
-tyrosine, and 3, 5-halogenated-
l<...
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Full title
Rational design of environmentally responsive antibodies with pH-sensing synthetic amino acids
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TN_cdi_doaj_primary_oai_doaj_org_article_b3974d48ef1640889cf0b0a808f2255b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b3974d48ef1640889cf0b0a808f2255b
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-024-70271-3
