TMED inhibition suppresses cell surface PD-1 expression and overcomes T cell dysfunction
TMED inhibition suppresses cell surface PD-1 expression and overcomes T cell dysfunction
About this item
Full title
Author / Creator
Vredevoogd, David W , Apriamashvili, Georgi , Levy, Pierre L , Sinha, Sanju , Huinen, Zowi R , Visser, Nils L , de Bruijn, Beaunelle , Boshuizen, Julia , van Hal-van Veen, Susan E , Ligtenberg, Maarten A , Bleijerveld, Onno B , Lin, Chun-Pu , Díaz-Gómez, Judit , Sánchez, Santiago Duro , Markovits, Ettai , Simon Nieto, Juan , van Vliet, Alex , Krijgsman, Oscar , Markel, Gal , Besser, Michal J , Altelaar, Maarten , Ruppin, Eytan and Peeper, Daniel S
Publisher
England: BMJ Publishing Group Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BMJ Publishing Group Ltd
Subjects
More information
Scope and Contents
Contents
BackgroundBlockade of the programmed cell death protein 1 (PD-1) immune checkpoint (ICB) is revolutionizing cancer therapy, but little is known about the mechanisms governing its expression on CD8 T cells. Because PD-1 is induced during activation of T cells, we set out to uncover regulators whose inhibition suppresses PD-1 abundance without advers...
Alternative Titles
Full title
TMED inhibition suppresses cell surface PD-1 expression and overcomes T cell dysfunction
Authors, Artists and Contributors
Author / Creator
Apriamashvili, Georgi
Levy, Pierre L
Sinha, Sanju
Huinen, Zowi R
Visser, Nils L
de Bruijn, Beaunelle
Boshuizen, Julia
van Hal-van Veen, Susan E
Ligtenberg, Maarten A
Bleijerveld, Onno B
Lin, Chun-Pu
Díaz-Gómez, Judit
Sánchez, Santiago Duro
Markovits, Ettai
Simon Nieto, Juan
van Vliet, Alex
Krijgsman, Oscar
Markel, Gal
Besser, Michal J
Altelaar, Maarten
Ruppin, Eytan
Peeper, Daniel S
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b3b1db25d0594fcdad82ad2a293ad050
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b3b1db25d0594fcdad82ad2a293ad050
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2024-010145
