Elucidating Microglial Heterogeneity and Functions in Alzheimer’s Disease Using Single-cell Analysis...
Elucidating Microglial Heterogeneity and Functions in Alzheimer’s Disease Using Single-cell Analysis and Convolutional Neural Network Disease Model Construction
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Author / Creator
Wu, Xinyi , Liu, Mingyu , Zhang, Xinyue , Pan, Xue , Cui, Xiaotong , Jin, Jiahui , Sun, Huanan , Xiao, Chuyu , Tong, Xiangyi , Ren, Liou , Wang, Yaxuan and Cao, Xuezhao
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
In this study, we conducted an in-depth exploration of Alzheimer's Disease (AD) by integrating state-of-the-art methodologies, including single-cell RNA sequencing (scRNA-seq), weighted gene co-expression network analysis (WGCNA), and a convolutional neural network (CNN) model. Focusing on the pivotal role of microglia in AD pathology, our analysis...
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Full title
Elucidating Microglial Heterogeneity and Functions in Alzheimer’s Disease Using Single-cell Analysis and Convolutional Neural Network Disease Model Construction
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TN_cdi_doaj_primary_oai_doaj_org_article_b3f66d6748d0496ca57de8349c1d0f29
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b3f66d6748d0496ca57de8349c1d0f29
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-024-67537-1
