Siah2 control of T-regulatory cells limits anti-tumor immunity
Siah2 control of T-regulatory cells limits anti-tumor immunity
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in
Siah2
−/−
mice. Growth-inhibited tumors exhibit increased numbers of intra-tumoral activated T cells and decreased expressio...
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Full title
Siah2 control of T-regulatory cells limits anti-tumor immunity
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TN_cdi_doaj_primary_oai_doaj_org_article_b4571c9b4e094486a2056a1668569d65
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b4571c9b4e094486a2056a1668569d65
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13826-7
