Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulatin...
Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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5′-aminolevulinate synthase (ALAS) catalyzes the first step in heme biosynthesis, generating 5′-aminolevulinate from glycine and succinyl-CoA. Inherited frameshift indel mutations of human erythroid-specific isozyme ALAS2, within a C-terminal (Ct) extension of its catalytic core that is only present in higher eukaryotes, lead to gain-of-function X-...
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Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release
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TN_cdi_doaj_primary_oai_doaj_org_article_b469b0462bc94b0e8a1d29a9113fb32b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b469b0462bc94b0e8a1d29a9113fb32b
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16586-x
