A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neu...
A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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We describe a human single-nuclei transcriptomic atlas for the substantia nigra (SN), generated by sequencing approximately 17,000 nuclei from matched cortical and SN samples. We show that the common genetic risk for Parkinson’s disease (PD) is associated with dopaminergic neuron (DaN)-specific gene expression, including mitochondrial functioning,...
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A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders
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TN_cdi_doaj_primary_oai_doaj_org_article_b479fe2c43c740f2a5200c552a91eb31
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b479fe2c43c740f2a5200c552a91eb31
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17876-0
