Cryo-EM structures of full-length integrin αIIbβ3 in native lipids
Cryo-EM structures of full-length integrin αIIbβ3 in native lipids
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Platelet integrin αIIbβ3 is maintained in a bent inactive state (low affinity to physiologic ligand), but can rapidly switch to a ligand-competent (high-affinity) state in response to intracellular signals (“inside-out” activation). Once bound, ligands drive proadhesive “outside-in” signaling. Anti-αIIbβ3 drugs like eptifibatide can engage the inac...
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Full title
Cryo-EM structures of full-length integrin αIIbβ3 in native lipids
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TN_cdi_doaj_primary_oai_doaj_org_article_b492d27f5ecf4a52879de123c3081790
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b492d27f5ecf4a52879de123c3081790
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-39763-0
