Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer...
Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
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Author / Creator
Zhong, Li , Xu, Ying , Zhuo, Rengong , Wang, Tingting , Wang, Kai , Huang, Ruizhi , Wang, Daxin , Gao, Yue , Zhu, Yifei , Sheng, Xuan , Chen, Kai , Wang, Na , Zhu, Lin , Can, Dan , Marten, Yuka , Shinohara, Mitsuru , Liu, Chia-Chen , Du, Dan , Sun, Hao , Wen, Lei , Xu, Huaxi , Bu, Guojun and Chen, Xiao-Fen
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor genetically linked to the risk for Alzheimer’s disease (AD). A proteolytic product, soluble TREM2 (sTREM2), is abundant in the cerebrospinal fluid and its levels positively correlate with neuronal injury markers. To gain insights into the pathological roles of...
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Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
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TN_cdi_doaj_primary_oai_doaj_org_article_b52435dfcf7a4d5aa13e0d196ad259a1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b52435dfcf7a4d5aa13e0d196ad259a1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09118-9
