SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations
SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations
About this item
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Vascular networks form, remodel and mature under the influence of both fluid shear stress (FSS) and soluble factors. Physiological FSS promotes and maintains vascular stability via synergy with Bone Morphogenic Protein 9 (BMP9) and BMP10. Conversely, mutation of the BMP receptors ALK1, Endoglin or the downstream effector SMAD4 leads to Hereditary H...
Alternative Titles
Full title
SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b542650ec401437cb3c92d2af512b770
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b542650ec401437cb3c92d2af512b770
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI168352
