The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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The NLRP3 inflammasome has an important function in inflammation by promoting the processing of pro-IL-1β and pro-IL-18 to their mature bioactive forms, and by inducing cell death via pyroptosis. Here we show a critical function of the E3 ubiquitin ligase Pellino2 in facilitating activation of the NLRP3 inflammasome. Pellino2-deficient mice and mye...
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Full title
The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
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TN_cdi_doaj_primary_oai_doaj_org_article_b58516ad7891424abe4c474bec6c5209
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b58516ad7891424abe4c474bec6c5209
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-03669-z
