Analysis of the anti-tumor effect of cetuximab using protein kinetics and mouse xenograft models
Analysis of the anti-tumor effect of cetuximab using protein kinetics and mouse xenograft models
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Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
The binding of EGFR and its ligands leads to autophosphorylation of receptor tyrosine kinase as well as subsequent activation of signal transduction pathways that are involved in regulating cellular proliferation, differentiation, and survival. An EGFR inhibitor, cetuximab binds to EGFR and consequently blocks a variety of cellular processes. KRAS/...
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Full title
Analysis of the anti-tumor effect of cetuximab using protein kinetics and mouse xenograft models
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TN_cdi_doaj_primary_oai_doaj_org_article_b58d51c2f3e0430aa03d513f06ee8f32
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b58d51c2f3e0430aa03d513f06ee8f32
Other Identifiers
ISSN
1756-0500
E-ISSN
1756-0500
DOI
10.1186/1756-0500-4-140
