Telomere dysfunction activates YAP1 to drive tissue inflammation
Telomere dysfunction activates YAP1 to drive tissue inflammation
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Full title
Author / Creator
Chakravarti, Deepavali , Hu, Baoli , Mao, Xizeng , Rashid, Asif , Li, Jiexi , Li, Jun , Liao, Wen-ting , Whitley, Elizabeth M. , Dey, Prasenjit , Hou, Pingping , LaBella, Kyle A. , Chang, Andrew , Wang, Guocan , Spring, Denise J. , Deng, Pingna , Zhao, Di , Liang, Xin , Lan, Zhengdao , Lin, Yiyun , Sarkar, Sharmistha , Terranova, Christopher , Deribe, Yonathan Lissanu , Blutt, Sarah E. , Okhuysen, Pablo , Zhang, Jianhua , Vilar, Eduardo , Nielsen, Ole Haagen , Dupont, Andrew , Younes, Mamoun , Patel, Kalyani R. , Shroyer, Noah F. , Rai, Kunal , Estes, Mary K. , Wang, Y. Alan , Bertuch, Alison A. and DePinho, Ronald A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Germline telomere maintenance defects are associated with an increased incidence of inflammatory diseases in humans, yet whether and how telomere dysfunction causes inflammation are not known. Here, we show that telomere dysfunction drives pATM/c-ABL-mediated activation of the YAP1 transcription factor, up-regulating the major pro-inflammatory fact...
Alternative Titles
Full title
Telomere dysfunction activates YAP1 to drive tissue inflammation
Authors, Artists and Contributors
Author / Creator
Hu, Baoli
Mao, Xizeng
Rashid, Asif
Li, Jiexi
Li, Jun
Liao, Wen-ting
Whitley, Elizabeth M.
Dey, Prasenjit
Hou, Pingping
LaBella, Kyle A.
Chang, Andrew
Wang, Guocan
Spring, Denise J.
Deng, Pingna
Zhao, Di
Liang, Xin
Lan, Zhengdao
Lin, Yiyun
Sarkar, Sharmistha
Terranova, Christopher
Deribe, Yonathan Lissanu
Blutt, Sarah E.
Okhuysen, Pablo
Zhang, Jianhua
Vilar, Eduardo
Nielsen, Ole Haagen
Dupont, Andrew
Younes, Mamoun
Patel, Kalyani R.
Shroyer, Noah F.
Rai, Kunal
Estes, Mary K.
Wang, Y. Alan
Bertuch, Alison A.
DePinho, Ronald A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b5a35bee98a746039f8bae5793248657
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b5a35bee98a746039f8bae5793248657
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18420-w
