Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for...
Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Best1 and Best2 are two members of the bestrophin family of anion channels critically involved in the prevention of retinal degeneration and maintenance of intraocular pressure, respectively. Here, we solved glutamate- and γ-aminobutyric acid (GABA)-bound Best2 structures, which delineate an intracellular glutamate binding site and an extracellular...
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Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment
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TN_cdi_doaj_primary_oai_doaj_org_article_b5bf1810ca514d98bba32bc385eccbf7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b5bf1810ca514d98bba32bc385eccbf7
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-54938-z
