Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myel...
Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma
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Author / Creator
Maclachlan, Kylee H. , Rustad, Even H. , Derkach, Andriy , Zheng-Lin, Binbin , Yellapantula, Venkata , Diamond, Benjamin , Hultcrantz, Malin , Ziccheddu, Bachisio , Boyle, Eileen M. , Blaney, Patrick , Bolli, Niccolò , Zhang, Yanming , Dogan, Ahmet , Lesokhin, Alexander M. , Morgan, Gareth J. , Landgren, Ola and Maura, Francesco
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Chromothripsis is detectable in 20–30% of newly diagnosed multiple myeloma (NDMM) patients and is emerging as a new independent adverse prognostic factor. In this study we interrogate 752 NDMM patients using whole genome sequencing (WGS) to investigate the relationship of copy number (CN) signatures to chromothripsis and show they are highly associ...
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Full title
Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma
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TN_cdi_doaj_primary_oai_doaj_org_article_b5e6a8716f6d4f72afb2988be3482362
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b5e6a8716f6d4f72afb2988be3482362
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25469-8
