The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damag...
The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
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Author / Creator
Ha, Kyungsoo , Ma, Chengxian , Lin, Han , Tang, Lichun , Lian, Zhusheng , Zhao, Fang , Li, Ju-Mei , Zhen, Bei , Pei, Huadong , Han, Suxia , Malumbres, Marcos , Jin, Jianping , Chen, Huan , Zhao, Yongxiang , Zhu, Qing and Zhang, Pumin
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Double-strand breaks (DSBs) are repaired through two major pathways, homology-directed recombination (HDR) and non-homologous end joining (NHEJ). While HDR can only occur in S/G2, NHEJ can happen in all cell cycle phases (except mitosis). How then is the repair choice made in S/G2 cells? Here we provide evidence demonstrating that APC
Cdh1
pl...
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Full title
The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
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TN_cdi_doaj_primary_oai_doaj_org_article_b6255a7494034e8ba37a58fd202bf3a6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b6255a7494034e8ba37a58fd202bf3a6
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15751
