Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
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Author / Creator
Schmidt, Sebastian , Luecken, Malte D. , Trümbach, Dietrich , Hembach, Sina , Niedermeier, Kristina M. , Wenck, Nicole , Pflügler, Klaus , Stautner, Constantin , Böttcher, Anika , Lickert, Heiko , Ramirez-Suastegui, Ciro , Ahmad, Ruhel , Ziller, Michael J. , Fitzgerald, Julia C. , Ruf, Viktoria , van de Berg, Wilma D. J. , Jonker, Allert J. , Gasser, Thomas , Winner, Beate , Winkler, Jürgen , Vogt Weisenhorn, Daniela M. , Giesert, Florian , Theis, Fabian J. and Wurst, Wolfgang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental factors. However, underlying pathological mechanisms remain poorly understood. Using multiplexed single-cell transcriptomics, we analyze human neural precursor cells (hNPCs) from sporadic PD (sPD) patients. Alterations in gene express...
Alternative Titles
Full title
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
Authors, Artists and Contributors
Author / Creator
Luecken, Malte D.
Trümbach, Dietrich
Hembach, Sina
Niedermeier, Kristina M.
Wenck, Nicole
Pflügler, Klaus
Stautner, Constantin
Böttcher, Anika
Lickert, Heiko
Ramirez-Suastegui, Ciro
Ahmad, Ruhel
Ziller, Michael J.
Fitzgerald, Julia C.
Ruf, Viktoria
van de Berg, Wilma D. J.
Jonker, Allert J.
Gasser, Thomas
Winner, Beate
Winkler, Jürgen
Vogt Weisenhorn, Daniela M.
Giesert, Florian
Theis, Fabian J.
Wurst, Wolfgang
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b648848b74c14840be9be48f8be10660
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b648848b74c14840be9be48f8be10660
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32229-9
