Polypyrimidine tract-binding proteins are essential for B cell development
Polypyrimidine tract-binding proteins are essential for B cell development
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Publisher
England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We show that PTBP2 compensates for PTBP1 in B cell ontogeny as deletion of both Ptbp1 and Ptbp2 results in a complete block at t...
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Full title
Polypyrimidine tract-binding proteins are essential for B cell development
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TN_cdi_doaj_primary_oai_doaj_org_article_b68b2bc2ff684844afe3e2ee6dd99ca4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b68b2bc2ff684844afe3e2ee6dd99ca4
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.53557
