PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell a...
PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Myeloid cells play key roles in cancer immune suppression and tumor progression. In response to tumor derived factors, circulating monocytes and granulocytes extravasate into the tumor parenchyma where they stimulate angiogenesis, immune suppression and tumor progression. Chemokines, cytokines and interleukins stimulate PI3Kγ-mediated Rap1 activati...
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Full title
PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation
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TN_cdi_doaj_primary_oai_doaj_org_article_b6c618803fc74a3887178594aab67db6
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b6c618803fc74a3887178594aab67db6
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-29471-6
